| Tbio | Hepatoma-derived growth factor-related protein 3 |
Enhances DNA synthesis and may play a role in cell proliferation.
Comments
Property Summary
| NCBI Gene PubMed Count | 11 |
| Grant Count | 3 |
| Funding | $250,339.5 |
| PubMed Score | 2.12 |
| PubTator Score | 9.45 |
| Disease | log2 FC | p |
|---|---|---|
| gastric cancer | 1.100 | 0.006 |
| malignant mesothelioma | 1.600 | 0.000 |
| astrocytoma | -2.100 | 0.003 |
| ependymoma | -1.900 | 0.033 |
| psoriasis | -2.100 | 0.000 |
| glioblastoma | -1.800 | 0.000 |
| osteosarcoma | -2.790 | 0.000 |
| atypical teratoid / rhabdoid tumor | -1.700 | 0.001 |
| medulloblastoma, large-cell | -1.300 | 0.000 |
| Duchenne muscular dystrophy | 1.060 | 0.000 |
| juvenile dermatomyositis | 1.208 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -1.300 | 0.001 |
| intraductal papillary-mucinous carcinoma... | -2.700 | 0.001 |
| colon cancer | -2.300 | 0.026 |
| lung cancer | -2.100 | 0.000 |
| Breast cancer | 2.400 | 0.036 |
| adult high grade glioma | -1.700 | 0.000 |
| pilocytic astrocytoma | -1.100 | 0.004 |
| lung adenocarcinoma | -1.200 | 0.000 |
| nasopharyngeal carcinoma | 1.400 | 0.000 |
| lung carcinoma | 1.400 | 0.000 |
| ulcerative colitis | 1.400 | 0.001 |
| ovarian cancer | 1.500 | 0.000 |
| PMID | Text |
|---|---|
| 26823754 | Glucose deprivation-induced HRP-3 up-regulation potentially plays a major role in protecting hepatocellular carcinoma cells against apoptosis caused by energy pressure. |
| 24012673 | Depletion of HRP-3 induces apoptosis of radio- and chemoresistant A549 cells. HRP-3 is essential for regulating reactive oxygen species-dependent, p53-induced cell death. |
| 19237540 | Hepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neurons |
| 15371438 | LEDGF/p75 and HRP2 IBDs avidly bind HIV-1 Integrase, share a similar domain organization and have an evident evolutionary and likely functional relationship |
| PMID | Year | Title |
|---|---|---|
| 26823754 | 2015 | HRP-3 protects the hepatoma cells from glucose deprivation-induced apoptosis. |
| 24012673 | 2013 | Depletion of hepatoma-derived growth factor-related protein-3 induces apoptotic sensitization of radioresistant A549 cells via reactive oxygen species-dependent p53 activation. |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
| 19237540 | 2009 | Hepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neurons. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 15761153 | 2005 | High-throughput mapping of a dynamic signaling network in mammalian cells. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15371438 | 2004 | Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| More... |
