Property Summary

NCBI Gene PubMed Count 19
PubMed Score 139.25
PubTator Score 165.29

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
group 4 medulloblastoma 1875 2.35919916944199E-6
ovarian cancer 8492 1.11573311681174E-5
pituitary cancer 1972 4.07273602854057E-5
osteosarcoma 7933 1.24293475384997E-4
medulloblastoma, large-cell 6234 1.46405287237272E-4
dermatomyositis 967 6.91892283498272E-4
Multiple myeloma 1328 8.48722555488116E-4
glioblastoma 5572 0.0030563852109782
non primary Sjogren syndrome sicca 840 0.0128464456307274
acute myeloid leukemia 785 0.0252532215416755
subependymal giant cell astrocytoma 2287 0.0258027525047088
pulmonary arterial hypertension 36 0.0389085565037074
spina bifida 1064 0.0417764162876671


  Differential Expression (13)

Disease log2 FC p
Multiple myeloma 1.594 0.001
osteosarcoma -1.068 0.000
glioblastoma 1.400 0.003
group 4 medulloblastoma -1.800 0.000
medulloblastoma, large-cell 1.100 0.000
non primary Sjogren syndrome sicca 1.400 0.013
subependymal giant cell astrocytoma 1.662 0.026
pulmonary arterial hypertension -2.000 0.039
spina bifida -1.310 0.042
acute myeloid leukemia -1.100 0.025
ovarian cancer -1.700 0.000
pituitary cancer -1.200 0.000
dermatomyositis 1.600 0.001


Accession Q9Y3B8 B2R532 Q32Q18 Q53FT1 Q6FIC6 Q9UFY7
Symbols RFN


  Ortholog (14)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
Fruitfly OMA EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (6)

26147002 CBY1 downregulation in CML arises from reduced protein stability upon binding to 14-3-3sigma adapter protein. The ubiquitin proteasome system UPS participates in reducing stability of CBY1 bound with 14-3-3sigma through enhanced SUMOylation.
24102700 Loss of 14-3-3sigma sensitizes cells to UVB. After a transient cell cycle arrest, 14-3-3sigma-deficient cells die by undergoing mitotic catastrophe.
23741365 REXO2 is an oligoribonuclease active in human mitochondria and present both in cytosolic and mitochondrial fractions.
20877624 Observational study of gene-disease association. (HuGE Navigator)
18023590 The expression in E. coli of orn and homologues from Mycobacterium smegmatis and human, and large-scale purification of the three enzymes, is reported.
15362935 SFN expression is involved in resistance of RSa cells to UV-C-induced cell death through the roles it plays in the DNA repair process

AA Sequence

RNNIFKKKIDEKKRKIIENGENEKTVS                                               211 - 237

Text Mined References (26)

PMID Year Title
26147002 2015 14-3-3 Binding and Sumoylation Concur to the Down-Modulation of ?-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24129315 2014 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24102700 2013 The epithelium specific cell cycle regulator 14-3-3sigma is required for preventing entry into mitosis following ultraviolet B.
23741365 2013 REXO2 is an oligoribonuclease active in human mitochondria.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.