Property Summary

NCBI Gene PubMed Count 16
PubMed Score 6.77
PubTator Score 7.15

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Prostatic Neoplasms 471
Disease Target Count P-value
glioblastoma 5572 2.30992460440702E-7
ovarian cancer 8492 2.72182501456663E-5
adult high grade glioma 2148 4.46618099908413E-5
ulcerative colitis 2087 2.48362605740026E-4
invasive ductal carcinoma 2950 2.5919007646016E-4
interstitial cystitis 2299 7.83785269947866E-4
sonic hedgehog group medulloblastoma 1482 8.28602224244022E-4
medulloblastoma, large-cell 6234 0.0037605802994528
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0061589220588246
adrenocortical carcinoma 1427 0.00869459202599687
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00947745809331988
ductal carcinoma in situ 1745 0.0289521017779374

Expression

Synonym

Accession Q9Y365 O60532 PCTP-L
Symbols PCTP2
CGI-52
NY-CO-28
SDCCAG28

Gene

  Ortholog (8)

 GWAS Trait (1)

Gene RIF (7)

PMID Text
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20543867 A nonpredicted link between SNAI1-triggered EMT and the down-regulation of Nectin-1 and StarD10 through the up-regulation of miR-661, which may contribute to the invasion of breast cancer cells and poor disease outcome.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19676041 Data show that in multivariate analyses incorporating tumor size, tumor grade, lymph node status, ER, PR and HER2 status, low STARD10 expression was an independent predictor of death from breast cancer.
17561512 C-terminal StarD10 phosphorylation on serine 284 regulates its association with cellular membranes
15911624 StarD10 interacts with phosphatidylcholine and phosphatidylethanolamine and preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position
14576202 Stard10 (Sdccag28) is much more highly transcribed in mouse cardiac atria than in cardiac ventricles.

AA Sequence

MEKLAASTEPQGPRPVLGRESVQVPDDQDFRSFRSECEAEVGWNLTYSRAGVSVWVQAVEMDRTLHKIKC      1 - 70
RMECCDVPAETLYDVLHDIEYRKKWDSNVIETFDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMG     71 - 140
ADYIIMNYSVKHPKYPPRKDLVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPK    141 - 210
AMKKMYKACLKYPEWKQKHLPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVAESREERMGGAG    211 - 280
GEGSDDDTSLT                                                               281 - 291
//

Text Mined References (20)

PMID Year Title
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23850713 2014 Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
23514108 2013 Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of diverse ethnic origins.
23455924 2013 A Y2H-seq approach defines the human protein methyltransferase interactome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21269460 2011 Initial characterization of the human central proteome.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20543867 2010 miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19676041 2010 Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status.
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