SLC6A5
Sodium- and chloride-dependent glycine transporter 2
Protein Summary
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
- ENST00000525748
- ENSP00000434364
- ENSG00000165970
- GLYT2
- NET1
- NET1
- GLYT2
- HKPX3
- GLYT-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.95 | ||
cell type or tissue | 0.74 | ||
cell line | 0.61 | ||
PubMedID | 0.56 | ||
transcription factor | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 302.44 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 302.44 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 89
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0