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Tbio Ubiquitin-conjugating enzyme E2 D4

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.

 Comments

Property Summary

NCBI Gene PubMed Count 14
PubMed Score 1.25
PubTator Score 2.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
osteosarcoma 7950 1.8e-07
psoriasis 6694 1.4e-05
intraductal papillary-mucinous neoplasm (IPMN) 3291 1.1e-02

Expression

  Differential Expression (3)

Disease log2 FC p
intraductal papillary-mucinous neoplasm ... -1.200 1.1e-02
osteosarcoma 1.217 1.8e-07
psoriasis -2.100 1.4e-05

Synonym

Accession Q9Y2X8 A4D1V0
Symbols HBUCE1

Gene

UBE2D4

PANTHER Protein Class (1)

  Ortholog (2)

Species Source Disease
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (6)

 GO Function (3)

 GO Process (7)

 Compartment GO Term (4)

 HCA RNA Cell Line (56)

See all...

Pathway (8)

Protein-protein Interaction (9)

UBB   RNF25   UBAC1   HECTD1   URGCP   UHRF1   TRIP12   RNF10   OTUB1  

Gene RIF (1)

AA Sequence 

MALKRIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFT      1 - 70
TKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLARE     71 - 140
WTQKYAM                                                                   141 - 147
//

Text Mined References (14)

PMID Year Title