Tbio | Ubiquitin-conjugating enzyme E2 D4 |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.
Comments
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7933 | 1.77627057597052E-7 |
psoriasis | 6685 | 1.43917110755438E-5 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.0114634964949049 |
Disease | log2 FC | p |
---|---|---|
psoriasis | -2.100 | 0.000 |
osteosarcoma | 1.217 | 0.000 |
intraductal papillary-mucinous neoplasm ... | -1.200 | 0.011 |
PMID | Year | Title |
---|---|---|
25416956 | 2014 | A proteome-scale map of the human interactome network. |
21685362 | 2011 | The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. |
21516116 | 2011 | Next-generation sequencing to generate interactome datasets. |
20061386 | 2010 | The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. |
19690564 | 2009 | A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. |
19549727 | 2009 | Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. |
17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. |
16189514 | 2005 | Towards a proteome-scale map of the human protein-protein interaction network. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15231748 | 2004 | Functional proteomics mapping of a human signaling pathway. |
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