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Tbio Ubiquitin-conjugating enzyme E2 D4

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.

 Comments

Property Summary

NCBI Gene PubMed Count 13
PubMed Score 0.45
PubTator Score 2.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
osteosarcoma 7933 1.77627057597052E-7
psoriasis 6685 1.43917110755438E-5
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0114634964949049

Expression

  Differential Expression (3)

Disease log2 FC p
psoriasis -2.100 0.000
osteosarcoma 1.217 0.000
intraductal papillary-mucinous neoplasm ... -1.200 0.011

Synonym

Accession Q9Y2X8 A4D1V0
Symbols HBUCE1

Gene

UBE2D4

PANTHER Protein Class (1)

  Ortholog (1)

Species Source
Xenopus OMA Inparanoid

 GO Function (3)

 GO Process (7)

 Compartment GO Term (4)

 HCA RNA Cell Line (56)

See all...

Pathway (8)

 UniProt Keyword (6)

AA Sequence 

MALKRIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFT      1 - 70
TKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLARE     71 - 140
WTQKYAM                                                                   141 - 147
//

Text Mined References (13)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
21685362 2011 The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.
21516116 2011 Next-generation sequencing to generate interactome datasets.
20061386 2010 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
19690564 2009 A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.
19549727 2009 Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15231748 2004 Functional proteomics mapping of a human signaling pathway.
More...