Tdark SLC45A1 Proton-associated sugar transporter A

Protein Summary

Description

Proton-associated glucose transporter in the brain. This gene was isolated initially from a region on chromosome 1p that is frequently deleted in human neuroblastoma, although no causal relationship has since been demonstrated. The encoded protein belongs to the glycoside-pentoside-hexuronide cation symporter transporter family and may play a role in glucose uptake. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9Y2W3
• A0A0A0MT80
• Q5VY46
• Q5VY49
• PAST-A

Gene Name

• SLC45A1

Ensembl ID

• ENST00000471889
• ENSP00000418096
• ENSG00000162426

Symbol

• DNB5
• DNB5
• IDDNPF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.66
gene perturbation	0.53
cell type or tissue	0.51
cell line	0.5
chemical	0.44

Protein Classes

PANTHER Classes

Protein / Transporter / Carbohydrate Transporter / Proton-associated Sugar Transporter A

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc45 Family Of Putative Sugar Transporters / Proton-associated Sugar Transporter A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.89   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 12   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.89   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0