GPR55
G-protein coupled receptor 55
Protein Summary
May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
- ENST00000392039
- ENSP00000375893
- ENSG00000135898
- ENST00000392040
- ENSP00000375894
- ENST00000444078
- ENSP00000410267
- ENST00000622008
- ENSP00000482381
- LPIR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.86 | ||
tissue sample | 0.71 | ||
biological process | 0.63 | ||
cell type or tissue | 0.63 | ||
biological term | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 343.2 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 160 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 343.2 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 160 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 42
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2