Protein Summary
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
- ENST00000238018
- ENSP00000238018
- ENSG00000119125
- ENST00000358399
- ENSP00000351170
- ENST00000475764
- ENSP00000436619
- ENST00000545168
- ENSP00000437972
- KIAA1258
- GAH
- CYPIN
- GUANASE
- NEDASIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.79 | ||
small molecule perturbation | 0.73 | ||
microRNA | 0.66 | ||
cellular component | 0.57 | ||
gene perturbation | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.4 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 79.4 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0