Property Summary

NCBI Gene PubMed Count 20
Grant Count 7
R01 Count 4
Funding $307,591.16
PubMed Score 34.34
PubTator Score 52.04

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (26)

Disease log2 FC p
Waldenstrons macroglobulinemia -1.246 0.020
astrocytoma -2.400 0.013
ependymoma -1.400 0.030
psoriasis -1.200 0.000
glioblastoma -3.200 0.000
oligodendroglioma -1.300 0.000
osteosarcoma -2.594 0.000
group 4 medulloblastoma -2.200 0.000
atypical teratoid / rhabdoid tumor -4.200 0.000
medulloblastoma, large-cell 2.700 0.000
primitive neuroectodermal tumor -1.700 0.009
hereditary spastic paraplegia -1.066 0.013
limb girdle muscular dystrophy 2A -1.021 0.000
adrenocortical carcinoma -1.139 0.007
non-small cell lung cancer -2.534 0.000
intraductal papillary-mucinous carcinoma... 1.200 0.019
lung cancer -3.000 0.000
pediatric high grade glioma -2.700 0.000
pilocytic astrocytoma -1.700 0.000
primary Sjogren syndrome 1.100 0.001
Pick disease -2.400 0.000
progressive supranuclear palsy -2.200 0.008
Breast cancer -1.100 0.007
ulcerative colitis -1.400 0.000
ovarian cancer -2.400 0.000
pituitary cancer 1.400 0.000

Gene RIF (5)

PMID Text
25595798 Depletion of ATP8A1 impaired the asymmetric transbilayer distribution of phosphatidylserine in recycling endosomes, dissociated EHD1 from recycling endosomes, and generated aberrant endosomal tubules that appear resistant to fission.
23269685 the phospholipid flippase complex of ATP8A1 and CDC50A proteins has a role in cell migration
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
18519826 Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17229723 APLT has a role in macrophage-induced nitrosylation/oxidation plays an important role in cell clearance

AA Sequence

MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLY      1 - 70
SQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRN     71 - 140
GAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVD    141 - 210
SLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNS    211 - 280
TSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIIL    281 - 350
FNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQ    351 - 420
FKKCTIAGVAYGHVPEPEDYGCSPDEWQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTA    421 - 490
VPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIV    491 - 560
RTPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRAS    561 - 630
TSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCK    631 - 700
LLKKNMGMIVINEGSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKA    701 - 770
VICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYL    771 - 840
KNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGI    841 - 910
FERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLL    911 - 980
GNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIPMAPDMSGEAAMLFSSGV    981 - 1050
FWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVN   1051 - 1120
LYRSESLQQNLLHGYAFSQDENGIVSQSEVIRAYDTTKQRPDEW                             1121 - 1164
//

Text Mined References (25)

PMID Year Title
25595798 2015 Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.
25338677 Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23269685 2013 Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration.
22610502 2012 Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
21914794 2011 ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.
20961850 2010 CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.
20947505 2010 Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19946888 2010 Defining the membrane proteome of NK cells.
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