You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EFR3B
Protein EFR3 homolog B

Protein Summary
Description
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401432
  • ENSP00000386082
  • ENSG00000084710
  • ENST00000403714
  • ENSP00000384081
  • ENST00000405108
  • ENSP00000384454

Symbol
  • KIAA0953
  • KIAA0953
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
transcription factor perturbation
0.74
cell type or tissue
0.68
histone modification site profile
0.64
microRNA
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.81   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.81   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0