Property Summary

NCBI Gene PubMed Count 13
PubMed Score 8.08
PubTator Score 6.00

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 4.29257586303676E-18
lung adenocarcinoma 2714 1.20434749671723E-9
ovarian cancer 8492 1.32614720918597E-7
malignant mesothelioma 3163 2.00392024280068E-7
medulloblastoma 1524 1.75584704847601E-5
cystic fibrosis 1670 3.62048576794222E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 4.5479928001723E-5
acute quadriplegic myopathy 1157 5.61834383330455E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.69090549633091E-4
medulloblastoma, large-cell 6234 1.99632807159857E-4
primitive neuroectodermal tumor 3031 0.00147094491007932
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00537260029040244
lung cancer 4473 0.0064974828302644
colon cancer 1475 0.0241089618089487
Disease Target Count Z-score Confidence
Theileriasis 13 4.421 2.2



Accession Q9Y2B9 PKI-gamma
Symbols PKI-gamma


  Ortholog (8)

Gene RIF (6)

23963683 Results show that endogenous levels of Pkig reciprocally regulate osteoblast and adipocyte differentiation and that this reciprocal regulation is mediated in part by LIF.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
16870489 These results indicate that the downregulation of PKIgamma may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells.
11742798 Functional studies of the mouse homolog
9218452 Functional studies of the mouse homolog

AA Sequence

DGTTSS                                                                     71 - 76

Text Mined References (13)

PMID Year Title
23963683 2013 Protein kinase inhibitor ? reciprocally regulates osteoblast and adipocyte differentiation by downregulating leukemia inhibitory factor.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
16870489 2006 Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation.
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11978406 2002 Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors.
11780052 2001 The DNA sequence and comparative analysis of human chromosome 20.
11742798 2002 Vascular endothelial cells express isoforms of protein kinase A inhibitor.