PKIG
cAMP-dependent protein kinase inhibitor gamma
Protein Summary
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000349959
- ENSP00000338067
- ENSG00000168734
- ENST00000372886
- ENSP00000361977
- ENST00000372889
- ENSP00000361980
- ENST00000372891
- ENSP00000361981
- ENST00000372892
- ENSP00000361983
- ENST00000372894
- ENSP00000361985
- PKI-gamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.98 | ||
kinase perturbation | 0.91 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.83 | ||
gene perturbation | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.44 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 60 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.44 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 60 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0