Property Summary

NCBI Gene PubMed Count 170
Grant Count 155
R01 Count 82
Funding $28,057,543.15
PubMed Score 208.18
PubTator Score 183.21

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (9)

Disease log2 FC p
malignant mesothelioma -1.100 0.000
psoriasis 1.100 0.011
glioblastoma -1.800 0.000
osteosarcoma -1.441 0.000
atypical teratoid / rhabdoid tumor -1.200 0.000
sonic hedgehog group medulloblastoma -1.400 0.000
medulloblastoma, large-cell -1.400 0.000
adult high grade glioma -1.700 0.000
ovarian cancer -2.100 0.000

Synonym

Accession Q9Y297 B5MD49 Q5W141 Q5W142 Q9Y213
Symbols FWD1
FBW1A
FBXW1
bTrCP
FBXW1A
bTrCP1
betaTrCP
BETA-TRCP

Gene

PDB

1P22   2P64  

Gene RIF (157)

PMID Text
26666832 This study showed SCF(beta-TRCP) earmarks Set8 for ubiquitination and degradation in a casein kinase I-dependent manner, which is activated by DNA-damaging agents.
26506240 Low GAS7C increases cancer cell motility by promoting N-WASP/FAK/F-actin cytoskeleton dynamics. It also enhances beta-catenin stability via hnRNP U/beta-TrCP complex formation.
26497204 EBV-miR-BART10-3p facilitated epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC.
26317613 Vpu requires BTRC to degrade BST2 (tetherin) but does not require BTRC for Vpu-mediated BST2 (tetherin) antagonism
26009993 beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth
26004137 a model that CD166 regulates MCAM through a signaling flow from activation of PI3K/AKT and c-Raf/MEK/ERK signaling to the inhibition of potential MCAM ubiquitin E3 ligases, betaTrCP and Smurf1.
26003292 No evidence of a direct association between beta-TRCP polymorphisms and breast cancer.
25900982 SCF(beta-TrCP1/2) interacting partners, were identified.
25701827 These results show that human rotaviruses commonly inhibit the NF-kappaB pathway via their NSP1 protein by degrading beta-TrCP and thus stabilizing IkappaB.
25626907 Human rotavirus NSP1 functions by mimicking the host IkappaB phosphodegron recognized by beta-TrCP.
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AA Sequence

MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKII      1 - 70
PEKNSLRQTYNSCARLCLNQETVCLASTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKY     71 - 140
FEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAEL    141 - 210
VCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIE    211 - 280
TIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ    281 - 350
YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRR    351 - 420
VLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRL    421 - 490
WDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFR    491 - 560
LQFDEFQIVSSSHDDTILIWDFLNDPAAQAEPPRSPSRTYTYISR                             561 - 605
//

Text Mined References (181)

PMID Year Title
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
26666832 2015 SCF(?-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation.
26506240 2015 Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/?-TrCP/?-catenin pathways in lung cancer.
26497204 2015 EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC.
26009993 2015 A dominant-negative F-box deleted mutant of E3 ubiquitin ligase, ?-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice.
26004137 2015 CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and ?TrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells.
26003292 2015 Effect of TP53 16-bp and ?-TrCP 9-bp INS/DEL polymorphisms in relation to risk of breast cancer.
25900982 2015 BioID-based Identification of Skp Cullin F-box (SCF)?-TrCP1/2 E3 Ligase Substrates.
25873176 2015 TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis.
25704143 Cep68 can be regulated by Nek2 and SCF complex.
More...