Tbio ST3GAL6 Type 2 lactosamine alpha-2,3-sialyltransferase

Protein Summary

Description

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1. The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q9Y274
• B2RCH2
• B3KMI1
• D3DN39
• F8W6U0

Gene Name

• ST3GAL6

Ensembl ID

• ENST00000265261
• ENSP00000265261
• ENSG00000064225
• ENST00000394162
• ENSP00000377717
• ENST00000483910
• ENSP00000417376

Symbol

• SIAT10
• SIAT10
• ST3GALVI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.89
transcription factor perturbation	0.88
gene perturbation	0.83
virus perturbation	0.83
histone modification site profile	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.96   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 52   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.96   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0