| Tbio | RuvB-like 1 |
May be able to bind plasminogen at cell surface and enhance plasminogen activation.
This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 2.3e-19 |
| glioblastoma | 5792 | 8.5e-11 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.4e-08 |
| malignant mesothelioma | 3232 | 1.5e-07 |
| group 3 medulloblastoma | 4104 | 5.2e-07 |
| medulloblastoma, large-cell | 6241 | 2.1e-06 |
| primitive neuroectodermal tumor | 3035 | 1.7e-05 |
| adult high grade glioma | 3801 | 3.9e-05 |
| invasive ductal carcinoma | 2951 | 1.4e-04 |
| colon cancer | 1478 | 5.7e-04 |
| lung cancer | 4740 | 4.5e-03 |
| ovarian cancer | 8520 | 4.8e-03 |
| ependymoma | 4679 | 3.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Intermittent explosive disorder | 4 | 3.65 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 3.9e-05 |
| atypical teratoid / rhabdoid tumor | 1.700 | 1.4e-08 |
| colon cancer | 1.100 | 5.7e-04 |
| ependymoma | 1.800 | 3.6e-02 |
| glioblastoma | 1.400 | 8.5e-11 |
| group 3 medulloblastoma | 1.800 | 5.2e-07 |
| invasive ductal carcinoma | 1.300 | 1.4e-04 |
| lung cancer | 1.400 | 4.5e-03 |
| malignant mesothelioma | 1.700 | 1.5e-07 |
| medulloblastoma, large-cell | 2.500 | 2.1e-06 |
| non-small cell lung cancer | 1.389 | 2.3e-19 |
| ovarian cancer | 1.200 | 4.8e-03 |
| primitive neuroectodermal tumor | 1.700 | 1.7e-05 |
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKKMAGRAVLLAG 1 - 70 PPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIKETKEVYEGEVTELTP 71 - 140 CETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESLQKERVEAGDVIYIEANSGAVKRQGRCDTYA 141 - 210 TEFDLEAEEYVPLPKGDVHKKKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEIN 211 - 280 KVVNKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGI 281 - 350 PLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN 351 - 420 GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK 421 - 456 //
