Tbio ANGPT4 Angiopoietin-4

Protein Summary

Description

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis. Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y264
• B4E3J9
• Q5TFF4
• Q9H4Z4
• ANG-4

Gene Name

• ANGPT4

Ensembl ID

• ENST00000381922
• ENSP00000371347
• ENSG00000101280

Symbol

• ANG3
• ANG4
• ANG3
• ANG4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
protein domain	0.73
gene perturbation	0.62
cell type or tissue	0.61
molecular function	0.56

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Angiopoietin-4

DTO Classes

Protein / Signaling / Angiopoietin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.69   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.69   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0