Property Summary

NCBI Gene PubMed Count 13
Grant Count 3
R01 Count 3
Funding $236,496
PubMed Score 6.66
PubTator Score 6.78

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (17)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.404 0.018
Multiple myeloma 1.322 0.016
astrocytic glioma -1.100 0.045
osteosarcoma 1.163 0.043
atypical teratoid / rhabdoid tumor -1.800 0.000
glioblastoma -1.800 0.000
medulloblastoma -1.600 0.000
medulloblastoma, large-cell -2.100 0.000
primitive neuroectodermal tumor -1.400 0.000
hereditary spastic paraplegia -1.264 0.010
juvenile dermatomyositis 1.158 0.000
Parkinson's disease -1.300 0.042
Breast cancer 3.200 0.042
adult high grade glioma -1.400 0.015
primary Sjogren syndrome 1.100 0.039
ovarian cancer -1.100 0.007
Gaucher disease type 1 -1.800 0.003

Synonym

Accession Q9Y252 B4DDP0 Q5W0H0 Q9BZP5 Q9UF41
Symbols

Gene

Gene RIF (4)

PMID Text
26971355 This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia.
18368307 Results describe thet cloning and identification of a novel RNF6 transcriptional splice variant, Spg2, in human development.
16204183 Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics
11971979 Functional anaylysis of the mouse homolog

AA Sequence

MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNLLGTPGEITSE      1 - 70
ELQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRTGNATRSGQNGNQTWRAVSRT     71 - 140
NPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRDHTANRQQRSTSPVARRTRSQTSVNFNGSSS    141 - 210
NIPRTRLASRGQNPAEGSFSTLGRLRNGIGGAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHV    211 - 280
WENGARSNVTVRNTNQRLEPIRLRSTSNSRSRSPIQRQSGTVYHNSQRESRPVQQTTRRSVRRRGRTRVF    281 - 350
LEQDRERERRGTAYTPFSNSRLVSRITVEEGEESSRSSTAVRRHPTITLDLQVRRIRPGENRDRDSIANR    351 - 420
TRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSSVALRSILRQIMTG    421 - 490
FGELSSLMEADSESELQRNGQHLPDMHSELSNLGTDNNRSQHREGSSQDRQAQGDSTEMHGENETTQPHT    491 - 560
RNSDSRGGRQLRNPNNLVETGTLPILRLAHFFLLNESDDDDRIRGLTKEQIDNLSTRHYEHNSIDSELGK    561 - 630
ICSVCISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPVLGSNIANNG                   631 - 685
//

Text Mined References (16)

PMID Year Title
26971355 2016 The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1.
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
24509480 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
22159054 2011 A comprehensive genetic association study of Alzheimer disease in African Americans.
19345326 2009 Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.
18368307 2008 Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16204183 2005 The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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