Property Summary

NCBI Gene PubMed Count 18
PubMed Score 49.32
PubTator Score 36.59

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 8.89321104310374E-30
lung carcinoma 2844 1.11353527648111E-21
psoriasis 6685 1.30591786715834E-13
atypical teratoid / rhabdoid tumor 4369 5.91079033365429E-9
lung adenocarcinoma 2714 7.59433583364256E-9
group 3 medulloblastoma 2254 2.46845921340338E-8
Breast cancer 3099 3.17215234828637E-8
medulloblastoma, large-cell 6234 3.82983998632767E-6
adrenocortical carcinoma 1427 6.8376827672099E-6
lung cancer 4473 7.04159259971555E-6
pediatric high grade glioma 2712 8.55594701774988E-6
primitive neuroectodermal tumor 3031 1.22213962348993E-5
posterior fossa group A ependymoma 1511 1.46530044491013E-5
glioblastoma 5572 3.72973967930985E-5
pituitary cancer 1972 9.37995824420018E-5
ovarian cancer 8492 3.69075303717954E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 5.67262087503123E-4
breast carcinoma 1614 0.00108146444774768
invasive ductal carcinoma 2950 0.00138743970981278
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00293614008514137
acute myeloid leukemia 785 0.00627704221108557
ductal carcinoma in situ 1745 0.0127410406370189
Endometriosis 535 0.0311287973524223
osteosarcoma 7933 0.0442154711549672
Disease Target Count Z-score Confidence
Cancer 2346 3.204 1.6



Accession Q9Y248 D3DUM5 Q6IAG9
Symbols PSF2


PANTHER Protein Class (2)


2E9X   2EHO   2Q9Q  

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
Fruitfly OMA EggNOG Inparanoid
S.cerevisiae EggNOG Inparanoid

Gene RIF (5)

25348432 High GINS2 transcript level is associated with endocrine therapy resistance in beast cancer.
24273454 On the contrary, after HL60 cells were infected by recombinant adenovirus vector which contained GINS2 gene, we observed that over-expression of GINS2 could promote HL-60 cell proliferation.
23589040 GINS2 plays an important role in apoptosis and may function via the p38MAPK signaling pathway.
22474384 Data show that using a 200-nt primed circular DNA substrate, the combined action of DNA polymerase epsilon and the Cdc45/Mcm2-7/GINS (CMG complex) leads to the formation of products >10 kb in length.
21082043 Data suggest that GINS2 to be associated with the aggressive characteristics of a subgroup of breast cancers in vivo.

AA Sequence


Text Mined References (29)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25348432 2014 High GINS2 transcript level predicts poor prognosis and correlates with high histological grade and endocrine therapy resistance through mammary cancer stem cells in breast cancer patients.
24299456 2014 Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7.
24273454 2013 Effect of GINS2 on proliferation and apoptosis in leukemic cell line.
23589040 2013 Roles of GINS2 in K562 human chronic myelogenous leukemia and NB4 acute promyelocytic leukemia cells.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22540012 2012 Interactions of the human MCM-BP protein with MCM complex components and Dbf4.
22474384 2012 Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.