Tchem AKT3 RAC-gamma serine/threonine-protein kinase

Protein Summary

Description

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y243
• Q0VAA6
• Q5VTI1
• Q5VTI2
• Q96QV3
• Q9UFP5

Gene Name

• AKT3

Ensembl ID

• ENST00000263826
• ENSP00000263826
• ENSG00000117020
• ENST00000336199
• ENSP00000336943
• ENST00000366539
• ENSP00000355497
• ENST00000366540
• ENSP00000355498
• ENST00000613395
• ENSP00000479922
• ENSG00000275199
• ENST00000619536
• ENSP00000483054
• ENST00000621586
• ENSP00000479081

Symbol

• PKBG
• MPPH
• PKBG
• MPPH2
• PRKBG
• STK-2
• PKB-GAMMA
• RAC-gamma
• RAC-PK-gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
transcription factor perturbation	0.94
molecular function	0.91
microRNA	0.89
pathway	0.88

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Rac-gamma Serine/threonine-protein Kinase

Protein / Transfer/carrier Protein / Rac-gamma Serine/threonine-protein Kinase

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Rac-gamma Serine/threonine-protein Kinase

Protein / Calcium-binding Protein / Annexin / Rac-gamma Serine/threonine-protein Kinase

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Akt Family / Rac-gamma Serine/threonine-protein Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.97   (req: < 5)

Gene RIFs: 146   (req: <= 3)

Antibodies: 1054   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.97   (req: >= 5)

Gene RIFs: 146   (req: > 3)

Antibodies: 1054   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 102

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0