Property Summary

NCBI Gene PubMed Count 23
PubMed Score 12.43
PubTator Score 12.28

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (3)

Expression

  Differential Expression (1)

Disease log2 FC p
psoriasis 1.600 0.000

Synonym

Accession Q9Y241 Q9UFZ2
Symbols HIG1
RCF1a

Gene

PDB

2LOM  

Gene RIF (4)

PMID Text
23878241 Data indicate that hypoxia-induced gene domain protein-1a (Higd-1a) inhibits Optic atrophy 1 (Opa1) cleavage and is required for mitochondrial fusion by virtue of its interaction with Opa1.
23646141 Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.
22355194 depletion of HIG1 increased gamma-secretase activation and enhanced hypoxia-induced mitochondrial dysfunction
20877624 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MSTDTGVSLPSYEEDQGSKLIRKAKEAPFVPVGIAGFAAIVAYGLYKLKSRGNTKMSIHLIHMRVAAQGF      1 - 70
VVGAMTVGMGYSMYREFWAKPKP                                                    71 - 93
//

Text Mined References (25)

PMID Year Title
25605899 2015 Higd1a is a positive regulator of cytochrome c oxidase.
25187353 2014 Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
23878241 2013 Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria.
23646141 2013 Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
22609626 2012 Facile backbone structure determination of human membrane proteins by NMR spectroscopy.
22355194 2012 HIG1, a novel regulator of mitochondrial ?-secretase, maintains normal mitochondrial function.
22342701 2012 Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex.
21856340 2011 The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation.
21269460 2011 Initial characterization of the human central proteome.
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