Tbio | RING finger protein 24 |
May play a role in TRPCs intracellular trafficking.
This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
Comments
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2798 | 2.36045132474563E-15 |
psoriasis | 6685 | 1.67066324795114E-9 |
malignant mesothelioma | 3163 | 6.07450110250475E-8 |
Breast cancer | 3099 | 8.70608878947369E-8 |
pituitary cancer | 1972 | 2.45128509754241E-4 |
atypical teratoid / rhabdoid tumor | 4369 | 3.59723740572465E-4 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 4.3418294329117E-4 |
glioblastoma | 5572 | 4.93824940708168E-4 |
oligodendroglioma | 2849 | 8.00878028338447E-4 |
primitive neuroectodermal tumor | 3031 | 0.0013122492250018 |
medulloblastoma | 1524 | 0.00282769543354735 |
active ulcerative colitis | 477 | 0.00300291052316088 |
lung cancer | 4473 | 0.00324141994126203 |
gastric carcinoma | 832 | 0.00701114582641318 |
invasive ductal carcinoma | 2950 | 0.0108310118980184 |
astrocytic glioma | 2241 | 0.0163063253545851 |
medulloblastoma, large-cell | 6234 | 0.0176413368128821 |
osteosarcoma | 7933 | 0.031841814943987 |
Disease | log2 FC | p |
---|---|---|
malignant mesothelioma | -1.900 | 0.000 |
astrocytic glioma | 1.200 | 0.016 |
oligodendroglioma | 1.200 | 0.001 |
psoriasis | -1.400 | 0.000 |
osteosarcoma | -1.281 | 0.032 |
atypical teratoid / rhabdoid tumor | -1.200 | 0.000 |
glioblastoma | 1.100 | 0.000 |
medulloblastoma | -1.300 | 0.003 |
medulloblastoma, large-cell | -1.200 | 0.018 |
primitive neuroectodermal tumor | 1.100 | 0.001 |
non-small cell lung cancer | 1.046 | 0.000 |
intraductal papillary-mucinous neoplasm ... | 1.700 | 0.000 |
lung cancer | 1.100 | 0.003 |
active ulcerative colitis | 1.327 | 0.003 |
Breast cancer | 1.300 | 0.000 |
gastric carcinoma | 1.400 | 0.007 |
invasive ductal carcinoma | 1.200 | 0.011 |
pituitary cancer | -1.300 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
Zebrafish | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
17850865 | Results indicate that RNF24 interacts with TRPC cation channels in the Golgi apparatus and affects TRPC intracellular trafficking without affecting their activity. |
PMID | Year | Title |
---|---|---|
25416956 | 2014 | A proteome-scale map of the human interactome network. |
17850865 | 2008 | RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
11780052 | 2001 | The DNA sequence and comparative analysis of human chromosome 20. |
11042152 | 2000 | Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |