Tchem CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha

Protein Summary

Description

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018]

Uniprot Accession IDs

• Q9UQM7
• Q9UL21
• Q9Y2H4
• Q9Y352
• CaM kinase II subunit alpha

Gene Name

• CAMK2A

Ensembl ID

• ENST00000348628
• ENSP00000261793
• ENSG00000070808
• ENST00000398376
• ENSP00000381412

Symbol

• CAMKA
• KIAA0968
• CAMKA
• MRD53
• MRT63
• CaMKIINalpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
molecular function	0.98
protein domain	0.92
phosphatase	0.9
biological process	0.85

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camk2 Family / Calcium/calmodulin-dependent Protein Kinase Type Ii Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.95   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 813   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.95   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 813   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1