AGTPBP1
Cytosolic carboxypeptidase 1
Protein Summary
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]
- ENST00000357081
- ENSP00000349592
- ENSG00000135049
- ENST00000376083
- ENSP00000365251
- ENST00000628899
- ENSP00000487074
- CCP1
- KIAA1035
- NNA1
- CCP1
- NNA1
- CONDCA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.92 | ||
histone modification site profile | 0.88 | ||
kinase perturbation | 0.88 | ||
transcription factor binding site profile | 0.79 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.08 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 305 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.08 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 305 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0