Tbio CEP164 Centrosomal protein of 164 kDa

Protein Summary

Description

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q9UPV0
• Q6PKH9
• Q7Z2X9
• Q9NVS0
• Q9UFJ6
• Cep164

Gene Name

• CEP164

Ensembl ID

• ENST00000278935
• ENSP00000278935
• ENSG00000110274

Symbol

• KIAA1052
• NPHP15
• NPHP15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.75
transcription factor	0.75
virus perturbation	0.68
cell line	0.64
transcription factor binding site profile	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.2   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.2   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0