Property Summary

NCBI Gene PubMed Count 14
PubMed Score 16.76
PubTator Score 18.16

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Substance-Related Disorders 114
Disease Target Count P-value
breast carcinoma 1614 6.29945456510752E-22
lung carcinoma 2844 1.18406038727184E-16
non-small cell lung cancer 2798 8.68868215062901E-12
Duchenne muscular dystrophy 602 4.50503139570564E-9
ovarian cancer 8492 5.02016583352748E-9
group 4 medulloblastoma 1875 1.20107365871623E-8
juvenile dermatomyositis 1189 6.30991895554176E-8
limb girdle muscular dystrophy 2A 156 8.72253777518559E-7
lung adenocarcinoma 2714 1.44039364535143E-6
Breast cancer 3099 1.48297848699082E-6
acute quadriplegic myopathy 1157 5.84157043103955E-6
medulloblastoma, large-cell 6234 1.04009160017505E-5
lung cancer 4473 1.18465330417591E-5
psoriasis 6685 2.65699136490293E-5
Atopic dermatitis 944 7.58084520708212E-5
colon cancer 1475 8.1825744274643E-5
invasive ductal carcinoma 2950 3.17635495448304E-4
ductal carcinoma in situ 1745 4.16039274379163E-4
atypical teratoid / rhabdoid tumor 4369 4.3666940687802E-4
cutaneous lupus erythematosus 1056 5.69486501896837E-4
Amyotrophic Lateral Sclerosis 432 9.55499087529674E-4
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00227462812335835
tuberculosis 1563 0.0026199414537491
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0120043381400361
acute myeloid leukemia 785 0.0140991567651565
intraductal papillary-mucinous adenoma (IPMA) 2956 0.018689430142797
osteosarcoma 7933 0.036880978227773

Expression

Synonym

Accession Q9UPU9 A8MPZ5 Q0VA96 Q6PEW4 Smaug 1
Symbols SMG
SMGA
SAMD4
SMAUG
SMAUG1

Gene

  Ortholog (7)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Anole lizard OMA Inparanoid

Pathway (1)

Gene RIF (5)

PMID Text
22201125 The Smaug1 is expressed during synaptogenesis, and Smaug1 knockdown affected the number and size of synapses, and also provoked an impaired response to repetitive depolarizing stimuli, as indicated by a reduced induction of Arc/Arg3.1.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
16221671 Smaug 1 has a role in RNA granule formation and translation regulation in neurons

AA Sequence

MMFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSQTQARFLQLCLEHSLADCAELHVLEREANSPGIINQ      1 - 70
WQQESKDKVISLLLTHLPLLKPGNLDAKVEYMKLLPKILAHSIEHNQHIEESRQLLSYALIHPATSLEDR     71 - 140
SALAMWLNHLEDRTSTSFGGQNRGRSDSVDYGQTHYYHQRQNSDDKLNGWQNSRDSGICINASNWQDKSM    141 - 210
GCENGHVPLYSSSSVPTTINTIGTSTSTILSGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARG    211 - 280
PQCLPSDHAPLSPQSSVASSGSGGSEHLEDQTTARNTFQEEGSGMKDVPAWLKSLRLHKYAALFSQMTYE    281 - 350
EMMALTECQLEAQNVTKGARHKIVISIQKLKERQNLLKSLERDIIEGGSLRIPLQELHQMILTPIKAYSS    351 - 420
PSTTPEARRREPQAPRQPSLMGPESQSPDCKDGAAATGATATPSAGASGGLQPHQLSSCDGELAVAPLPE    421 - 490
GDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKCLIHEAFTETQKKRLLSWKQQVQKLFRSFPRKT    491 - 560
LLDISGYRQQRNRGFGQSNSLPTAGSVGGGMGRRNPRQYQIPSRNVPSARLGLLGTSGFVSSNQRNTTAT    561 - 630
PTIMKQGRQNLWFANPGGSNSMPSRTHSSVQRTRSLPVHTSPQNMLMFQQPEFQLPVTEPDINNRLESLC    631 - 700
LSMTEHALGDGVDRTSTI                                                        701 - 718
//

Text Mined References (19)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24023788 2013 Gene network analysis in a pediatric cohort identifies novel lung function genes.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
22201125 2011 Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
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