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Tbio
TNRC6B
Trinucleotide repeat-containing gene 6B protein

Protein Summary
Description
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301923
  • ENSP00000306759
  • ENSG00000100354
  • ENST00000335727
  • ENSP00000338371
  • ENST00000402203
  • ENSP00000384795
  • ENST00000454349
  • ENSP00000401946

Symbol
  • KIAA1093
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
pathway
0.99
virus perturbation
0.98
interacting protein
0.97
transcription factor perturbation
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.98   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.98   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0