Tbio LHX6 LIM/homeobox protein Lhx6

Protein Summary

Description

Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex (By similarity). This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9UPM6
• A6PVQ1
• A6PVQ2
• A8K1B2
• B7Z4D0
• H0YN76
• Q5T7S7
• Q5T7S8
• Q9NTK3
• Q9UPM5
• LIM homeobox protein 6

Gene Name

• LHX6

Ensembl ID

• ENST00000340587
• ENSP00000340137
• ENSG00000106852
• ENST00000373754
• ENSP00000362859
• ENST00000373755
• ENSP00000362860
• ENST00000394319
• ENSP00000377854
• ENST00000541397
• ENSP00000441464
• ENST00000559895
• ENSP00000475927

Symbol

• LHX6.1
• LHX6.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.81
tissue sample	0.76
small molecule perturbation	0.73
PubMedID	0.7
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Lim/homeobox Protein Lhx6

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Lim/homeobox Protein Lhx6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.31   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 289   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.31   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0