Property Summary

NCBI Gene PubMed Count 40
PubMed Score 25.72
PubTator Score 20.54

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Juvenile arthritis 124
Disease Target Count P-value
juvenile dermatomyositis 1189 1.63400663242253E-15
ovarian cancer 8492 3.48355639811608E-6
psoriasis 6685 7.60832361361058E-5
sonic hedgehog group medulloblastoma 1482 2.00650119039148E-4
osteosarcoma 7933 3.39417127446405E-4
primary pancreatic ductal adenocarcinoma 1271 0.00168922802199475
pancreatic cancer 2300 0.00185625001186059
Waldenstrons macroglobulinemia 765 0.0025911152800779
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00275083242570983
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00536907831818304
glioblastoma 5572 0.00583673187750213
astrocytoma 1493 0.0147226187275665
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0265269065112685

Expression

Synonym

Accession Q9UNF0 O95921 Q96HV9 Q9H0D3 Q9NPN1 Q9Y4V2
Symbols SDPII

Gene

PDB

3ABH   3ACO   3HAJ   3Q0K  

  Ortholog (14)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid
C. elegans OMA EggNOG

 MGI Term (1)

Gene RIF (16)

PMID Text
26092940 PACSIN2 phosphorylation decreases its membrane-binding activity, thereby decreasing its stabilizing effect on caveolae and triggering dynamin-mediated removal of caveolae.
24385601 PC1 modulates actin cytoskeleton rearrangements and directional cell migration through the Pacsin 2/N-Wasp complex.
23596323 Cooperation of MICAL-L1, pacsin 2 (syndapin2), and phosphatidic acid in tubular recycling endosome biogenesis.
23129763 a novel role for the F-BAR-domain protein PACSIN2 in regulating EGF receptor surface levels and EGF-induced downstream signaling.
22846425 These data indicate that polymorphism in PACSIN2 significantly modulates TPMT activity and influences the risk of GI toxicity associated with mercaptopurine therapy.
21807942 important role in the formation of plasma membrane caveolae
21693584 Data identify the BAR-domain protein PACSIN2 as a Rac1 interactor that regulates Rac1-mediated cell spreading and migration.
21610094 Results indicate that PACSIN2 mediates membrane sculpting by caveolin-1 in caveola morphology and recruits dynamin-2 for caveola fission.
21200149 PACSIN2 regulates cell spreading and cell migration, which are dependent on cyclin D1 expression.
20564319 Meta-analysis of gene-disease association. (HuGE Navigator)
More...

AA Sequence

MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARRWRQLV      1 - 70
EKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRK     71 - 140
AQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEK    141 - 210
SLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAV    211 - 280
EDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVPSN    281 - 350
PAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFD    351 - 420
DDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEAIQ        421 - 486
//

Text Mined References (47)

PMID Year Title
26092940 2015 Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25416956 2014 A proteome-scale map of the human interactome network.
24385601 2014 Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24013648 2013 Molecular composition and ultrastructure of the caveolar coat complex.
23596323 2013 Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23236520 2012 Versatile membrane deformation potential of activated pacsin.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
More...