Tchem ADAMTS5 A disintegrin and metalloproteinase with thrombospondin motifs 5

Protein Summary

Description

Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q9UNA0
• Q52LV4
• Q9UKP2
• ADAM-TS 5

Gene Name

• ADAMTS5

Ensembl ID

• ENST00000284987
• ENSP00000284987
• ENSG00000154736

Symbol

• ADAMTS11
• ADMP2
• ADMP-2
• ADAM-TS5
• ADAMTS-5
• ADAMTS11
• ADAM-TS 5
• ADAMTS-11
• ADAM-TS 11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
PubMedID	0.9
transcription factor perturbation	0.84
kinase perturbation	0.76
cell type or tissue	0.71

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.43   (req: < 5)

Gene RIFs: 107   (req: <= 3)

Antibodies: 473   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.43   (req: >= 5)

Gene RIFs: 107   (req: > 3)

Antibodies: 473   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 252

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0