Protein Summary
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
- ENST00000298684
- ENSP00000298684
- ENSG00000165795
- ENST00000298687
- ENSP00000298687
- ENST00000350792
- ENSP00000344620
- ENST00000360463
- ENSP00000353649
- ENST00000397844
- ENSP00000380943
- ENST00000397847
- ENSP00000380945
- ENST00000397851
- ENSP00000380949
- ENST00000397853
- ENSP00000380951
- ENST00000397858
- ENSP00000380956
- ENST00000403829
- ENSP00000385889
- ENST00000553503
- ENSP00000452306
- ENST00000554143
- ENSP00000452006
- ENST00000555158
- ENSP00000452038
- ENST00000556147
- ENSP00000451712
- KIAA1248
- SYLD
- SYLD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
disease perturbation | 0.98 | ||
PubMedID | 0.9 | ||
transcription factor perturbation | 0.88 | ||
kinase | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.32 (req: < 5)
Gene RIFs: 130 (req: <= 3)
Antibodies: 358 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.32 (req: >= 5)
Gene RIFs: 130 (req: > 3)
Antibodies: 358 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0