Property Summary

NCBI Gene PubMed Count 24
PubMed Score 37.85
PubTator Score 65.53

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
oligodendroglioma 2849 1.66746101125736E-5
posterior fossa group B ependymoma 1530 2.31150079408712E-5
ovarian cancer 8492 2.94750590816015E-5
invasive ductal carcinoma 2950 0.00223944219507161
breast carcinoma 1614 0.00299999819768048
ductal carcinoma in situ 1745 0.00309020977794107
active ulcerative colitis 477 0.0049650144932892
subependymal giant cell astrocytoma 2287 0.00622898008953405
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0063669142601295
pediatric high grade glioma 2712 0.00721943350850603
atypical teratoid/rhabdoid tumor 1095 0.0143528880642551
Disease Target Count Z-score Confidence
Alzheimer's disease 644 0.0 1.0



Accession Q9UMX3 hBOK
Symbols BOKL



PANTHER Protein Class (1)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
Zebrafish OMA EggNOG Inparanoid

 IMPC Term (1)

 GWAS Trait (1)

Gene RIF (11)

24806027 Data suggest that hypoxia-induced expression of BOK in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A, HIF2A/EPAS1, HIF1B/ARNT) but is not affected by its antisense transcript.
24113155 First evidence for a key role of the BOK-MCL1 system in regulating autophagy in the human placenta, whereby an adverse environment as seen in preeclampsia tilts the BOK-MCL1 balance toward the build-up of isoforms that triggers placental autophagy.
23884412 Bok may govern IP3R cleavage and activity during apoptosis.
20673843 The results suggest important roles for Bok and Bcl-X(L) in human ovarian development, follicle maturation and apoptosis.
19942931 Data conclude that Mtd-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd found in PE may contribute to increased trophoblast proliferation.
19287972 BOKAS is a natural antisense transcript that regulates the pro-apoptotic activity of human Bok
16772296 Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 family
16302269 a link between the apoptotic activity and nuclear localization of a pro-apoptotic Bok
15868100 Studies showed that hBok was distributed in both the cytosol and intracellular membranes of healthy cells.
15775999 A novel Mtd/BOK splice isoform is responsible for trophoblast cell death in pre-eclampsia.

AA Sequence

ER                                                                        211 - 212

Text Mined References (26)

PMID Year Title
27505430 2016 Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak.
27076518 2016 Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak.
24806027 2014 Hypoxia-inducible regulation of placental BOK expression.
24113155 2013 Placental autophagy regulation by the BOK-MCL1 rheostat.
23884412 2013 The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.
23535732 2013 Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
20673843 2010 Regulation of cell death in human fetal and adult ovaries--role of Bok and Bcl-X(L).
20171287 2010 Voxelwise genome-wide association study (vGWAS).
19942931 2010 Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.