| Tbio | Mammalian ependymin-related protein 1 |
The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Glaucoma, Angle-Closure | 7 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Angle Closure Glaucoma | 7 |
| Disease | Target Count | P-value |
|---|---|---|
| oligodendroglioma | 2850 | 7.8e-10 |
| cystic fibrosis | 1696 | 1.6e-08 |
| non-small cell lung cancer | 2890 | 6.3e-07 |
| psoriasis | 6694 | 1.2e-06 |
| pituitary cancer | 1972 | 1.3e-06 |
| group 3 medulloblastoma | 4104 | 1.1e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 8.9e-05 |
| primitive neuroectodermal tumor | 3035 | 1.4e-04 |
| medulloblastoma, large-cell | 6241 | 1.4e-04 |
| head and neck cancer | 271 | 2.0e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 2.8e-04 |
| pancreatic cancer | 2398 | 1.2e-03 |
| invasive ductal carcinoma | 2951 | 1.3e-03 |
| Pick disease | 1894 | 3.1e-03 |
| Breast cancer | 3578 | 3.7e-03 |
| ductal carcinoma in situ | 1745 | 3.8e-03 |
| breast carcinoma | 1638 | 4.3e-03 |
| ovarian cancer | 8520 | 2.2e-02 |
| gastric carcinoma | 807 | 2.8e-02 |
| astrocytic glioma | 2597 | 2.9e-02 |
| fibroadenoma | 559 | 3.3e-02 |
| ependymoma | 4679 | 3.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Connective tissue disease | 62 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Primary angle-closure glaucoma | 14 | 4.375 | 2.2 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.300 | 2.9e-02 |
| atypical teratoid / rhabdoid tumor | -1.800 | 8.9e-05 |
| Breast cancer | -1.100 | 3.7e-03 |
| breast carcinoma | -1.200 | 4.3e-03 |
| cystic fibrosis | -4.318 | 1.6e-08 |
| ductal carcinoma in situ | -1.500 | 3.8e-03 |
| ependymoma | -1.500 | 3.5e-02 |
| fibroadenoma | -1.600 | 3.3e-02 |
| gastric carcinoma | 1.300 | 2.8e-02 |
| group 3 medulloblastoma | -3.100 | 1.1e-05 |
| head and neck cancer | -2.000 | 2.0e-04 |
| invasive ductal carcinoma | 1.064 | 1.3e-03 |
| medulloblastoma, large-cell | -2.500 | 1.4e-04 |
| non-small cell lung cancer | -1.182 | 6.3e-07 |
| oligodendroglioma | -1.100 | 7.8e-10 |
| ovarian cancer | 1.300 | 2.2e-02 |
| pancreatic cancer | 1.500 | 1.2e-03 |
| Pick disease | -1.600 | 3.1e-03 |
| pituitary cancer | 1.800 | 1.3e-06 |
| primary pancreatic ductal adenocarcinoma | 1.965 | 2.8e-04 |
| primitive neuroectodermal tumor | -1.800 | 1.4e-04 |
| psoriasis | -1.100 | 1.2e-06 |
