| Tbio | Mammalian ependymin-related protein 1 |
The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]
Comments
Property Summary
| NCBI Gene PubMed Count | 16 |
| Grant Count | 1 |
| R01 Count | 1 |
| Funding | $92,154 |
| PubMed Score | 15.45 |
| PubTator Score | 12.96 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.300 | 0.029 |
| ependymoma | -1.500 | 0.035 |
| oligodendroglioma | -1.100 | 0.000 |
| group 4 medulloblastoma | -3.300 | 0.000 |
| cystic fibrosis | -4.318 | 0.000 |
| atypical teratoid / rhabdoid tumor | -1.800 | 0.000 |
| medulloblastoma, large-cell | -2.500 | 0.000 |
| primitive neuroectodermal tumor | -1.800 | 0.000 |
| primary pancreatic ductal adenocarcinoma | 1.965 | 0.000 |
| non-small cell lung cancer | -1.182 | 0.000 |
| breast carcinoma | -1.200 | 0.004 |
| fibroadenoma | -1.600 | 0.033 |
| invasive ductal carcinoma | -1.800 | 0.014 |
| psoriasis | -1.100 | 0.000 |
| Pick disease | -1.600 | 0.003 |
| Breast cancer | -1.600 | 0.010 |
| gastric carcinoma | 1.300 | 0.028 |
| ductal carcinoma in situ | -1.500 | 0.004 |
| ovarian cancer | 1.300 | 0.022 |
| pituitary cancer | 1.800 | 0.000 |
| pancreatic cancer | 1.500 | 0.001 |
| head and neck cancer | -2.000 | 0.000 |
| PMID | Text |
|---|---|
| 24089297 | Results of this study suggest that EPDR1 gene can be added to a growing list of genes associated with Dupuytren's disease development. |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18374504 | Observational study of gene-disease association. (HuGE Navigator) |
| 16954209 | Shows that the mouse ortholog is a lysosomal protein. |
| PMID | Year | Title |
|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 24089297 | 2013 | Common variants of the EPDR1 gene and the risk of Dupuytren’s disease. |
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| 21732829 | 2011 | Wnt signaling and Dupuytren's disease. |
| 20556588 | 2010 | Effects of combined siRNA-TR and -TERT on telomerase activity and growth of bladder transitional cell cancer BIU-87 cells. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 19159218 | 2009 | Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. |
| 18374504 | 2008 | Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer. |
| 17302986 | 2007 | Molecular evolution of the ependymin protein family: a necessary update. |
| 16954209 | 2006 | Demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method. |
| More... |
