Property Summary

NCBI Gene PubMed Count 34
Grant Count 6
R01 Count 5
Funding $866,600.5
PubMed Score 54.13
PubTator Score 36.97

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession Q9ULX3 Q7L6B7 Q7M4M4 Q7Z4B5 Q9NWB0
Symbols ART-4
NOB1P
MST158
MSTP158
PSMD8BP1

Gene

Gene RIF (23)

PMID Text
26743688 we suggest that targeting miR-192 and NOB1 is a novel strategy which will assist in the development of new therapeutics that will be used in the future to prevent and treat prostate cancer.
26370469 The results suggested that NOB1 is important in OSCC development and serves as a candidate indicator of aggressiveness and a therapeutic target of oral squamous cell carcinoma.
26178254 These results suggest that NOB1 may act as an important regulator in non-small cell lung cancer growth and could be a therapeutic target of nonsmall cell lung cancer.
26122232 NOB1 protein in gastric cancer tissue and adjacent normal tissue was diffusely expressed in the cytoplasm and nucleus. NOB1 protein and mRNA expression was higher than normal in gastric cancer tissue and was directly related to tumor size.
25760058 Downregulation of miR-326 inhibited tumor proliferation and tumor metastasis by directly targeting NOB1 in colorectal carcinoma. Upregulation of miR-326 in CRC cells was revealed to be associated with a feedback loop involving downregulation of the NOB1.
25624720 NOB1 gene silencing by lentivirus-mediated RNA interference can inhibit tumor growth by inducing apoptosis of cancerous human colorectal cells.
25503472 These findings suggest that NOB1 may be a potential prognostic indicator for PCa.
25450647 Enhanced expression of NOB1 is related to poor overall survival and progression-free survival in patients with resected non-small cell lung cancer.
25420906 NOB1 expression was associated with poor prognosis in ccRCC patients.
25231838 Downregulation of NOB1 was able to significantly activate constitutive phosphorylation of p38 MAPK, which might contribute to the inhibition of papillary thyroid carcinoma cell growth.
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AA Sequence

MAPVEHVVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFKEPLPEYVRLVTEFS      1 - 70
KKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQEPQKVKVSSSIQHPETPLHISGFHLPYKPKPPQET     71 - 140
EKGHSACEPENLEFSSFMFWRNPLPNIDHELQELLIDRGEDVPSEEEEEEENGFEDRKDDSDDDGGGWIT    141 - 210
PSNIKQIQQELEQCDVPEDVRVGCLTTDFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDM    211 - 280
SRVFCSHCGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAINPHLTEDQRFPQLR    281 - 350
LSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQVRDSTLGAGRRRLNPNASRKKFVKKR            351 - 412
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Text Mined References (43)

PMID Year Title
26743688 2016 MiR-192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein.
26370469 2015 Downregulation of NOB1 inhibits proliferation and promotes apoptosis in human oral squamous cell carcinoma.
26178254 2015 Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation.
26122232 EXPRESSION MECHANISM AND CLINICAL SIGNIFICANCE OF NOB1 IN GASTRIC CANCER TISSUE AND ADJACENT NORMAL TISSUE.
25760058 2015 MicroRNA-326 functions as a tumor suppressor in colorectal cancer by targeting the nin one binding protein.
25624720 2015 NOB1 is essential for the survival of RKO colorectal cancer cells.
25503472 2015 Positive nin one binding protein expression predicts poor outcome in prostate cancer.
25450647 2015 Relationship between NOB1 expression and prognosis of resected non-small cell lung cancer.
25420906 2015 Evaluation of NIN/RPN12 binding protein inhibits proliferation and growth in human renal cancer cells.
25231838 2014 Adenovirus-mediated siRNA targeting NOB1 inhibits tumor growth and enhances radiosensitivity of human papillary thyroid carcinoma in vitro and in vivo.
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