Tbio CBLC E3 ubiquitin-protein ligase CBL-C

Protein Summary

Description

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q9ULV8
• Q8N1E5
• Q9Y5Z2
• Q9Y5Z3

Gene Name

• CBLC

Ensembl ID

• ENST00000270279
• ENSP00000270279
• ENSG00000142273
• ENST00000341505
• ENSP00000340250
• ENST00000647358
• ENSP00000494162

Symbol

• CBL3
• RNF57
• CBL-3
• RNF57
• CBL-SL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.86
hub protein	0.82
cell type or tissue	0.71
biological process	0.67

Protein Classes

PANTHER Classes

Protein / Ligase / E3 Ubiquitin-protein Ligase Cbl-c

DTO Classes

Protein / Enzyme / Ligase / E3 Ubiquitin-protein Ligase Cbl-c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.96   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 344   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.96   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0