Property Summary

NCBI Gene PubMed Count 36
PubMed Score 34.30
PubTator Score 22.89

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung adenocarcinoma 2714 3.57791186195188E-16
posterior fossa group A ependymoma 1511 2.6565599552143E-9
oligodendroglioma 2849 3.87979030246938E-9
psoriasis 6685 4.23228897074614E-8
pilocytic astrocytoma 3086 6.76984438352576E-8
malignant mesothelioma 3163 4.78560674829655E-7
group 3 medulloblastoma 2254 2.31064522792646E-6
medulloblastoma, large-cell 6234 1.08900644027557E-5
pediatric high grade glioma 2712 2.54408796875494E-5
Pick disease 1893 1.23368873964751E-4
atypical teratoid / rhabdoid tumor 4369 0.00271693271549424
glioblastoma 5572 0.00278267342612403
Atopic dermatitis 944 0.00350860179845333
interstitial cystitis 2299 0.00809736676143369
esophageal adenocarcinoma 737 0.0176010007179145
astrocytic glioma 2241 0.0222028317849294
adrenocortical carcinoma 1427 0.0299931282260889
Disease Target Count Z-score Confidence
Gastrointestinal system disease 50 0.0 1.0


  Differential Expression (17)

Disease log2 FC p
malignant mesothelioma 1.600 0.000
astrocytic glioma -1.300 0.022
esophageal adenocarcinoma -1.300 0.018
psoriasis 1.100 0.000
glioblastoma -2.100 0.003
oligodendroglioma -1.200 0.000
posterior fossa group A ependymoma -2.000 0.000
group 3 medulloblastoma -3.100 0.000
atypical teratoid / rhabdoid tumor -2.300 0.003
medulloblastoma, large-cell -3.400 0.000
Atopic dermatitis 1.100 0.004
adrenocortical carcinoma -2.134 0.030
interstitial cystitis -1.300 0.008
lung adenocarcinoma -1.300 0.000
pediatric high grade glioma -2.300 0.000
pilocytic astrocytoma -1.400 0.000
Pick disease -2.100 0.000


Accession Q9ULP0 B3KNU2 B4DK66 B4DSW5 H7C600 Q6ZNE7 Q6ZTI7 Q96PL9 Q9GZM1 Q9GZN3 Q9GZX0
Symbols BDM1


  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Xenopus OMA Inparanoid

Gene RIF (16)

26976975 Study shows that NDRG4 was significantly up-regulated in glioblastomas (GBM) and seems to play a role in GBM prognosis. These results indicate that NDRG4 gene in MGMT-methylated cells is a putative tumor-suppressor gene and an oncogene in cells with unmethylated MGMT.
26053091 These findings bring novel insight to the roles of NDRG4 in meningioma progression
25520251 Two downregulated genes, NDRG4 and GINS3, have been located in a genomic interval associated with cardiac repolarization in published GWASs and zebra fish knockout models
25241110 A homozygous variant in NDRG4 may be the causative variant of the autosomal recessive form of infantile myofibromatosis.
24993691 Methylation level in stool decreases dramatically following colorectal cancer resection
23725756 summarizes the current research on NDRG3 and NDRG4,including the molecular structure, cellular and tissue distribution, biological function, and function in cancer.
22869042 NDRG4 is involved in modulating cell proliferation, invasion, migration and angiogenesis in meningioma, and may play a valuable role as a molecular target in its treatment
22489821 Over expression of NDRG4 inhibited proliferation of GBM cells.
22399192 expression of NDRG4 is downregulated in human gliomas. The glioma patients with lower NDRG4 expression have a poor prognosis.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

AA Sequence

SC                                                                        351 - 352

Text Mined References (37)

PMID Year Title
26976975 2016 NDRG2 and NDRG4 Expression Is Altered in Glioblastoma and Influences Survival in Patients with MGMT-methylated Tumors.
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
26053091 2015 NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells.
25520251 2015 Adipose tissue gene expression and metabolic health of obese adults.
25416956 2014 A proteome-scale map of the human interactome network.
25241110 Exome sequencing identifies a novel homozygous variant in NDRG4 in a family with infantile myofibromatosis.
24993691 2014 Stool methylated DNA markers decrease following colorectal cancer resection--implications for surveillance.
23725756 2013 NDRG3 and NDRG4, two novel tumor-related genes.
22869042 2012 NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas.
22726844 2012 A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.