Property Summary

NCBI Gene PubMed Count 23
PubMed Score 4.88
PubTator Score 12.08

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 6.19531815959698E-17
hepatocellular carcinoma 550 1.99326565655334E-6
osteosarcoma 7933 8.66680068151488E-6
lung cancer 4473 2.55706398694045E-4
ovarian cancer 8492 3.59184990314328E-4
Multiple myeloma 1328 0.00156553655249484
Waldenstrons macroglobulinemia 765 0.00252312453103301
astrocytic glioma 2241 0.0229378030503038


  Differential Expression (8)

Disease log2 FC p
hepatocellular carcinoma 1.100 0.000
Waldenstrons macroglobulinemia 1.420 0.003
Multiple myeloma 1.543 0.002
astrocytic glioma -1.600 0.023
osteosarcoma -1.623 0.000
non-small cell lung cancer 1.035 0.000
lung cancer 1.600 0.000
ovarian cancer 2.300 0.000


Accession Q9ULC4 B4DGY2 Q502X6 MCT-1
Symbols MCT1


PANTHER Protein Class (1)



  Ortholog (16)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid
C. elegans OMA Inparanoid
Fruitfly OMA EggNOG Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Pathway (1)

Gene RIF (10)

23258846 Overexpression of MCT1 is associated with gliomas.
22336915 MCT-1 is a new centrosomal-associated oncoprotein, and that it plays a novel role in the regulation of mitosis signifies its important function in the process of tumorigenesis.
21138557 The oppositions between MCT-1 and p53 are firstly confirmed at multistage processes that include transcription control, mRNA metabolism, and protein expression
20823576 The present study indicates possible involvement of a protein kinase (PK)C- and PKA-mediated pathway associated with expression of MCT1 and lactate transport in rhabdomyosarcoma cells.
20658178 The result suggest that co-expression of CD147 and MCT1/MCT4 is related to drug resistance during EOC metastasis and could be useful therapeutic targets to prevent the development of incurable, recurrent and drug resistance EOC.
20076993 Results describe the expression and purification of MCT-1 in insect cells using a baculovirus expression system.
19372582 Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity.
18824261 role of the MCT-1 in lymphomagenesis
12938157 demonstrated the presence of sequence-specific DNA-binding protein in nuclear extracts designated as LMBF; the 26-mer oligonucleotide containing the LMBF binding site is required for maximum transcriptional activity of the MCT-1 promoter
12637315 tumor cell lines overexpressing MCT-1 exhibited increased growth rates and displayed increased protection against apoptosis induced by serum starvation

AA Sequence

HALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK                                 141 - 181

Text Mined References (33)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25043021 2014 DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth.
23258846 2013 Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
22336915 2012 The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21269460 2011 Initial characterization of the human central proteome.
21138557 2010 The antagonism between MCT-1 and p53 affects the tumorigenic outcomes.
20823576 2010 Regulation of monocarboxylate transporter 1 in skeletal muscle cells by intracellular signaling pathways.
20713520 2010 Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.
20658178 2010 Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression.