Property Summary

NCBI Gene PubMed Count 18
PubMed Score 789.82
PubTator Score 1709.35

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 3.16664898561129E-27
lung cancer 4473 4.2373718431942E-7
ovarian cancer 8492 1.89562653173534E-5
cystic fibrosis 1670 2.007893692515E-5
non-small cell lung cancer 2798 4.65349777051969E-5
medulloblastoma 1524 2.68730024132745E-4
atypical teratoid / rhabdoid tumor 4369 3.84136738732876E-4
medulloblastoma, large-cell 6234 8.38911898558791E-4
adult high grade glioma 2148 0.00503699650044777
glioblastoma 5572 0.0102643670089489
Pick disease 1893 0.0122894117457294
chronic lymphosyte leukemia 232 0.0159809432964655
ependymoma 2514 0.0180928118425286
astrocytic glioma 2241 0.0291008868367992
Breast cancer 3099 0.0347804936595105
osteosarcoma 7933 0.0440750341202128
aldosterone-producing adenoma 664 0.0443857108520313

Expression

  Differential Expression (17)

Disease log2 FC p
astrocytic glioma -1.100 0.029
ependymoma -1.100 0.018
glioblastoma -1.800 0.010
osteosarcoma 1.671 0.044
chronic lymphosyte leukemia 1.700 0.016
medulloblastoma -1.700 0.000
cystic fibrosis -1.304 0.000
atypical teratoid / rhabdoid tumor -2.400 0.000
medulloblastoma, large-cell -2.600 0.001
non-small cell lung cancer -1.318 0.000
lung cancer -4.100 0.000
adult high grade glioma -1.300 0.005
aldosterone-producing adenoma -1.042 0.044
Breast cancer -1.300 0.035
lung carcinoma 2.000 0.000
Pick disease -1.400 0.012
ovarian cancer -2.200 0.000

Synonym

Accession Q9UL42 B3KNY9 O94959 O95145 Q49A18 Q9UL43
Symbols MA2
MM2
RGAG2

Gene

PANTHER Protein Class (1)

  Ortholog (5)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid

Gene RIF (3)

PMID Text
27003254 PNMA2 functions as antagonist of MOAP-1 and PNMA1 through heterodimeric interaction
21729305 Immunohistochemical analysis of MA2/D2-40 combined with p16(INK4A) may have a significant implication in clinical practice for better identifying the grade of cervical intraepithelial neoplasia.
21209860 Ma2 may have a role in early recurrence of small intestine neuroendocrine tumors

AA Sequence

MALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQENANAVLLELL      1 - 70
EDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPE     71 - 140
LLAHLLGQAMAHAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAEKKRWLAESL    141 - 210
RGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQVRYLKTYQEEGEKVSAYVLRLETLLRRAV    211 - 280
EKRAIPRRIADQVRLEQVMAGATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPE    281 - 350
ERDGYGRWNHEGDD                                                            351 - 364
//

Text Mined References (20)

PMID Year Title
27003254 2016 PNMA2 mediates heterodimeric interactions and antagonizes chemo-sensitizing activities mediated by members of PNMA family.
25416956 2014 A proteome-scale map of the human interactome network.
21729305 2011 Decreased D2-40 and increased p16INK4A immunoreactivities correlate with higher grade of cervical intraepithelial neoplasia.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21269460 2011 Initial characterization of the human central proteome.
21209860 2010 Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors.
19366867 2009 Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner.
17474147 2007 Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
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