Tbio NUP50 Nuclear pore complex protein Nup50

Protein Summary

Description

Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UKX7
• B1AHA4
• B2RB15
• O75644
• Q8N6V5
• Q9NPM9
• Q9NPR6
• Q9P1K5

Gene Name

• NUP50

Ensembl ID

• ENST00000347635
• ENSP00000345895
• ENSG00000093000
• ENST00000396096
• ENSP00000379403
• ENST00000407019
• ENSP00000385555

Symbol

• NPAP60L
• NPAP60
• NPAP60L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
transcription factor perturbation	0.96
disease perturbation	0.95
virus perturbation	0.95
microRNA	0.94

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.36   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.36   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0