Tbio ACSL6 Long-chain-fatty-acid--CoA ligase 6

Protein Summary

Description

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• Q9UKU0
• J3KPG3
• O94924
• O95829
• Q108M9
• Q108N0
• Q4G191
• Q86TN7

Gene Name

• ACSL6

Ensembl ID

• ENST00000296869
• ENSP00000296869
• ENSG00000164398
• ENST00000357096
• ENSP00000349608
• ENST00000379240
• ENSP00000368542
• ENST00000379244
• ENSP00000368546
• ENST00000379246
• ENSP00000368548
• ENST00000379255
• ENSP00000368557
• ENST00000379264
• ENSP00000368566
• ENST00000543479
• ENSP00000442124

Symbol

• ACS2
• FACL6
• KIAA0837
• LACS5
• ACS2
• FACL6
• LACS2
• LACS5
• LACS 6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.96
molecular function	0.93
cellular component	0.79
disease perturbation	0.74
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Ligase / Long-chain-fatty-acid--coa Ligase 6

DTO Classes

Protein / Enzyme / Ligase / Long-chain-fatty-acid--coa Ligase 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.64   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.64   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0