Protein Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
- ENST00000316737
- ENSP00000319486
- ENSG00000130167
- ENST00000337994
- ENSP00000338759
- ENST00000590327
- ENSP00000467341
- ENST00000592955
- ENSP00000466751
- ENST00000621731
- ENSP00000480759
- TM4SF16
- TM-8
- TM4-B
- TM4SF16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
phenotype | 1 | ||
cell type or tissue | 0.63 | ||
kinase perturbation | 0.54 | ||
cell line | 0.48 | ||
tissue sample | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.89 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 58 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 243.89 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 58 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0