Tbio ADAMTS6 A disintegrin and metalloproteinase with thrombospondin motifs 6

Protein Summary

Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9UKP5
• Q59EX6
• Q5IR87
• Q5IR88
• Q5IR89
• Q68DL1
• ADAM-TS 6

Gene Name

• ADAMTS6

Ensembl ID

• ENST00000381052
• ENSP00000424377
• ENSG00000049192
• ENST00000381055
• ENSP00000370443

Symbol

• ADAM-TS6
• ADAMTS-6
• ADAM-TS 6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
histone modification site profile	0.87
virus perturbation	0.79
transcription factor binding site profile	0.73
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.63   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.63   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0