Tbio CASP8AP2 CASP8-associated protein 2

Protein Summary

Description

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• Q9UKL3
• A2RUB7
• E1P553
• Q6PH76
• Q7LCQ7
• Q86YD9
• Q9NUQ4
• Q9NZV9
• Q9P2N1
• Q9Y563

Gene Name

• CASP8AP2

Symbol

• FLASH
• KIAA1315
• RIP25
• CED-4
• FLASH
• RIP25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
molecular function	0.86
histone modification site profile	0.8
biological process	0.79
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Casp8-associated Protein 2

DTO Classes

Protein / Transcription Factor / Casp8-associated Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.66   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.66   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0