| Tbio | REST corepressor 1 |
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colonic Neoplasms | 142 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 3.0e-05 |
| adult high grade glioma | 3801 | 2.0e-04 |
| sonic hedgehog group medulloblastoma | 467 | 1.3e-03 |
| ovarian cancer | 8520 | 3.1e-03 |
| dermatomyositis | 966 | 4.4e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Allergic hypersensitivity disease | 126 | 3.551 | 1.8 |
| FG syndrome | 16 | 3.322 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.100 | 2.0e-04 |
| dermatomyositis | 1.100 | 4.4e-03 |
| medulloblastoma, large-cell | -1.100 | 3.0e-05 |
| ovarian cancer | 1.600 | 3.1e-03 |
| sonic hedgehog group medulloblastoma | 1.200 | 1.3e-03 |
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQN 1 - 70 KSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSP 71 - 140 NQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFH 141 - 210 GKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQN 211 - 280 KESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKR 281 - 350 QIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQV 351 - 420 KNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS 421 - 485 //
