Tdark GPATCH8 G patch domain-containing protein 8

Protein Summary

Description

The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q9UKJ3
• B9EGP9
• O60300
• Q8TB99

Gene Name

• GPATCH8

Ensembl ID

• ENST00000587228
• ENSP00000468719
• ENSG00000186566
• ENST00000591680
• ENSP00000467556

Symbol

• GPATC8
• KIAA0553
• GPATC8
• KIAA0553

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
disease perturbation	0.98
virus perturbation	0.94
cell line	0.71
microRNA	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.61   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.61   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0