Tbio POU2F3 POU domain, class 2, transcription factor 3

Protein Summary

Description

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen. This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q9UKI9
• A8K7H8
• B4DY07
• F5GWW6
• Q3MIY3
• Q9UKR7
• Q9Y504

Gene Name

• POU2F3

Ensembl ID

• ENST00000260264
• ENSP00000260264
• ENSG00000137709
• ENST00000543440
• ENSP00000441687

Symbol

• OTF11
• PLA1
• PLA1
• OCT11
• PLA-1
• Epoc-1
• OCT-11
• OTF-11
• Skn-1a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
disease perturbation	0.83
molecular function	0.81
biological process	0.78
kinase perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 512.31   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 512.31   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0