Property Summary

NCBI Gene PubMed Count 14
PubMed Score 7.27
PubTator Score 4.44

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
lung adenocarcinoma 2714 1.28445642563798E-6
nasopharyngeal carcinoma 1056 2.72882445441031E-5
psoriasis 6685 2.06436985885413E-4
interstitial cystitis 2299 0.00349332043647952
osteosarcoma 7933 0.00358974041787362
aldosterone-producing adenoma 664 0.0484376212502095


  Differential Expression (6)

Disease log2 FC p
psoriasis 1.200 0.000
osteosarcoma -1.284 0.004
interstitial cystitis 2.300 0.003
aldosterone-producing adenoma 2.629 0.048
lung adenocarcinoma 1.100 0.000
nasopharyngeal carcinoma -1.500 0.000


Accession Q9UKI3 B2R587
Symbols 8HS20


  Ortholog (6)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Chicken OMA EggNOG Inparanoid

Gene RIF (7)

25861052 A possible role for VPREB3 in aldosterone biosynthesis.
25861052 levels of VPREB3 mRNA in aldosterone-producing adenomas directly correlate to plasma aldosterone concentrations in peripheral blood of respective patients
24493312 the combined immunohistochemical detection of VPREB3 and ID3 is applicable to the routine diagnostic in case of mature aggressive B-cell lymphomas.
20823132 Data show that the absence of VpreB3 is virtually always associated with wild-type c-MYC alleles.
15757909 the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation.
14670953 VpreB3 may play a role in the regulation of the maturation and secretion of free IgLC in chicken B cells
8491176 mouse VpreB3 associates with mu heavy chains early in pre-B cell receptor biosynthesis

AA Sequence


Text Mined References (15)

PMID Year Title
25861052 2015 Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues.
24493312 2014 The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas.
20823132 2010 The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker for identifying c-MYC translocated lymphomas.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
15757909 2005 Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15461802 2004 A genome annotation-driven approach to cloning the human ORFeome.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14670953 2004 Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.