Property Summary

NCBI Gene PubMed Count 29
PubMed Score 26.00
PubTator Score 15.03

Knowledge Summary

Patent (61,164)

TINX Plot

  Disease Sources (6)

Disease Target Count P-value
non-small cell lung cancer 2798 2.08349685806268E-12
malignant mesothelioma 3163 1.94666090597354E-9
lung cancer 4473 6.35408393700314E-7
cystic fibrosis 1670 1.10884403126098E-6
interstitial cystitis 2299 5.38345363102082E-6
Pick disease 1893 7.61763967249552E-5
osteosarcoma 7933 1.5318386291127E-4
sonic hedgehog group medulloblastoma 1482 4.67760626109461E-4
head and neck cancer 270 6.52650501883181E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00107704457607346
subependymal giant cell astrocytoma 2287 0.00110787717939358
ulcerative colitis 2087 0.00131754132990172
ductal carcinoma in situ 1745 0.0022358930502702
invasive ductal carcinoma 2950 0.00268648918218966
oligodendroglioma 2849 0.0111905268771118
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0113479866120901
primary pancreatic ductal adenocarcinoma 1271 0.018032955948101
atypical teratoid / rhabdoid tumor 4369 0.0180837979357562
pancreatic cancer 2300 0.0207667655901999
esophageal adenocarcinoma 737 0.0214020317316477
adrenocortical carcinoma 1427 0.022811048836325
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Cardiovascular system disease 194 0.0 1.0
Disease Target Count Z-score Confidence
Intellectual disability 573 0.0 4.0

Expression

Gene

PDB

2X7F   5AX9   5CWZ   5D7A  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
C. elegans OMA EggNOG

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (10)

PMID Text
26645429 Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK.
26499327 High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients.
25160513 nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma
23355318 Dynamic change of TNIK offers a way to protect cells from outside stimulus.
22904686 TNIK mediates proliferation and survival of EBV-transformed B-cells.
21710359 TNIK is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and serves as a pro-survival factor.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19023125 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
18519826 Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15342639 TNIK is a specific effector of Rap2 to regulate actin cytoskeleton

AA Sequence

MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEI      1 - 70
NMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG     71 - 140
LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATY    141 - 210
DFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPAT    211 - 280
EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTL    281 - 350
RRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE    351 - 420
REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQ    421 - 490
RQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRIS    491 - 560
DPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTS    561 - 630
HRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLG    631 - 700
SQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSP    701 - 770
VLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE    771 - 840
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSG    841 - 910
EKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR    911 - 980
VYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEI    981 - 1050
LCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRN   1051 - 1120
RILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQH   1121 - 1190
KPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED   1191 - 1260
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCER   1261 - 1330
NDKVFFASVRSGGSSQVFFMTLNRNSMMNW                                           1331 - 1360
//

Text Mined References (42)

PMID Year Title
26645429 2016 Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK.
26499327 2015 Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer.
25160513 2014 Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23355318 2013 Dynamic change of TNIK in response to tumor necrosis factor alpha in a TRAF2-dependent manner.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22904686 2012 The germinal center kinase TNIK is required for canonical NF-?B and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.
22797597 2012 Rap2A links intestinal cell polarity to brush border formation.
22020285 2011 Image-based genome-wide siRNA screen identifies selective autophagy factors.
21710359 2011 Enormous influence of TNIK knockdown on intracellular signals and cell survival.
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