| Tbio | Calcipressin-3 |
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
Comments
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -2.700 | 0.000 |
| astrocytic glioma | -2.500 | 0.008 |
| group 4 medulloblastoma | 2.300 | 0.001 |
| cystic fibrosis | 1.093 | 0.000 |
| lung cancer | 1.300 | 0.001 |
| Breast cancer | 3.000 | 0.023 |
| pediatric high grade glioma | -1.300 | 0.026 |
| pilocytic astrocytoma | -1.300 | 0.014 |
| posterior fossa group B ependymoma | 1.600 | 0.000 |
| sarcoidosis | -1.300 | 0.000 |
| subependymal giant cell astrocytoma | -3.596 | 0.011 |
| lung carcinoma | 1.500 | 0.000 |
| progressive supranuclear palsy | -1.100 | 0.037 |
| invasive ductal carcinoma | 1.200 | 0.014 |
| acute myeloid leukemia | 1.500 | 0.037 |
| ovarian cancer | 1.300 | 0.003 |
| PMID | Text |
|---|---|
| 25916653 | The tumor suppressor effect of RCAN3 in breast cancer depends on the interaction with calcineurin. |
| 21961037 | Studies indicate that RCAN3 is composed of a multigene system that includes at least 21 alternative spliced isoforms. |
| 21042787 | Data shows RCAN3 inhibits HUVEC proliferation both basally and under VEGF or phorbol 12-myristate 13-acetate-stimulated conditions, however it does not modulate gene expression of the chosen inflammatory genes. |
| 19819266 | our data have elucidated the molecular and cellular mechanism whereby PGF(2alpha) regulates CXCL8 expression via the FP receptor in endometrial adenocarcinomas and have highlighted RCAN1-4 as a negative regulator of CXCL8 expression |
| 19074885 | Observational study of gene-disease association. (HuGE Navigator) |
| 18022329 | The interaction between TNNI3 and the new R variants of RCAN3, RCAN3-2,3,5 and RCAN3-2,4,5, is reported. |
| 17270291 | human RCAN3, encoded by the RCAN3 (also known as DSCR1L2) gene, interacts physically and functionally with calcineurin |
| 16516408 | The yeast cotransformation and GST fusion protein assay demonstrated the interaction between this new DSCR1L2 variant and the human cardiac troponin I. |
| PMID | Year | Title |
|---|---|---|
| 25916653 | 2015 | A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer. |
| 25814554 | 2015 | Phospho-tyrosine dependent protein-protein interaction network. |
| 21961037 | 2011 | Complexity of bidirectional transcription and alternative splicing at human RCAN3 locus. |
| 21042787 | 2010 | Human RCAN3 gene expression and cell growth in endothelial cells. |
| 19819266 | 2009 | Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway. |
| 19074885 | 2008 | Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. |
| 18022329 | 2008 | Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms. |
| 17270291 | 2007 | RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression. |
| 17081983 | 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
| More... |
