Tbio | Calcipressin-3 |
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
Comments
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2844 | 5.79429991160663E-19 |
malignant mesothelioma | 3163 | 8.33339940541736E-8 |
posterior fossa group B ependymoma | 1530 | 6.92759764665622E-7 |
sarcoidosis | 368 | 8.62576504029581E-6 |
cystic fibrosis | 1670 | 1.07751125502187E-4 |
group 4 medulloblastoma | 1875 | 6.0813588952412E-4 |
lung cancer | 4473 | 8.94429840933608E-4 |
ovarian cancer | 8492 | 0.00294161255165271 |
astrocytic glioma | 2241 | 0.0079153096769723 |
subependymal giant cell astrocytoma | 2287 | 0.0105013953225432 |
invasive ductal carcinoma | 2950 | 0.0139416772967712 |
pilocytic astrocytoma | 3086 | 0.0141750255975025 |
Breast cancer | 3099 | 0.02270138094331 |
pediatric high grade glioma | 2712 | 0.0259643018503408 |
acute myeloid leukemia | 785 | 0.0366766161359344 |
progressive supranuclear palsy | 674 | 0.0369479894169151 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Down syndrome | 548 | 3.818 | 1.9 |
Disease | log2 FC | p |
---|---|---|
malignant mesothelioma | -2.700 | 0.000 |
astrocytic glioma | -2.500 | 0.008 |
group 4 medulloblastoma | 2.300 | 0.001 |
cystic fibrosis | 1.093 | 0.000 |
lung cancer | 1.300 | 0.001 |
Breast cancer | 3.000 | 0.023 |
pediatric high grade glioma | -1.300 | 0.026 |
pilocytic astrocytoma | -1.300 | 0.014 |
posterior fossa group B ependymoma | 1.600 | 0.000 |
sarcoidosis | -1.300 | 0.000 |
subependymal giant cell astrocytoma | -3.596 | 0.011 |
lung carcinoma | 1.500 | 0.000 |
progressive supranuclear palsy | -1.100 | 0.037 |
invasive ductal carcinoma | 1.200 | 0.014 |
acute myeloid leukemia | 1.500 | 0.037 |
ovarian cancer | 1.300 | 0.003 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA Inparanoid |
Anole lizard | OMA Inparanoid |
C. elegans | OMA Inparanoid |
PMID | Text |
---|---|
25916653 | The tumor suppressor effect of RCAN3 in breast cancer depends on the interaction with calcineurin. |
21961037 | Studies indicate that RCAN3 is composed of a multigene system that includes at least 21 alternative spliced isoforms. |
21042787 | Data shows RCAN3 inhibits HUVEC proliferation both basally and under VEGF or phorbol 12-myristate 13-acetate-stimulated conditions, however it does not modulate gene expression of the chosen inflammatory genes. |
19819266 | our data have elucidated the molecular and cellular mechanism whereby PGF(2alpha) regulates CXCL8 expression via the FP receptor in endometrial adenocarcinomas and have highlighted RCAN1-4 as a negative regulator of CXCL8 expression |
19074885 | Observational study of gene-disease association. (HuGE Navigator) |
18022329 | The interaction between TNNI3 and the new R variants of RCAN3, RCAN3-2,3,5 and RCAN3-2,4,5, is reported. |
17270291 | human RCAN3, encoded by the RCAN3 (also known as DSCR1L2) gene, interacts physically and functionally with calcineurin |
16516408 | The yeast cotransformation and GST fusion protein assay demonstrated the interaction between this new DSCR1L2 variant and the human cardiac troponin I. |
PMID | Year | Title |
---|---|---|
25916653 | 2015 | A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer. |
25814554 | 2015 | Phospho-tyrosine dependent protein-protein interaction network. |
21961037 | 2011 | Complexity of bidirectional transcription and alternative splicing at human RCAN3 locus. |
21042787 | 2010 | Human RCAN3 gene expression and cell growth in endothelial cells. |
19819266 | 2009 | Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway. |
19074885 | 2008 | Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. |
18022329 | 2008 | Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms. |
17270291 | 2007 | RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression. |
17081983 | 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |
16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
More... |