| Tbio | Protein fem-1 homolog B |
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 4.0e-15 |
| juvenile dermatomyositis | 1187 | 8.7e-11 |
| acute quadriplegic myopathy | 1158 | 6.7e-08 |
| hepatocellular carcinoma | 547 | 2.0e-06 |
| malignant mesothelioma | 3232 | 1.1e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.4e-05 |
| glioblastoma | 5792 | 3.1e-05 |
| ovarian cancer | 8520 | 3.5e-04 |
| gastric cancer | 459 | 8.1e-04 |
| medulloblastoma, large-cell | 6241 | 1.3e-03 |
| dermatomyositis | 966 | 2.1e-03 |
| adult high grade glioma | 3801 | 2.8e-03 |
| group 4 medulloblastoma | 1855 | 3.5e-03 |
| pancreatic carcinoma | 562 | 7.1e-03 |
| pancreatic cancer | 2398 | 7.1e-03 |
| tuberculosis | 2010 | 1.0e-02 |
| Multiple myeloma | 1332 | 1.7e-02 |
| colon cancer | 1478 | 4.4e-02 |
| astrocytic glioma | 2597 | 5.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 2.097 | 6.7e-08 |
| adult high grade glioma | -1.100 | 2.8e-03 |
| astrocytic glioma | -1.100 | 5.0e-02 |
| atypical teratoid / rhabdoid tumor | -1.600 | 1.4e-05 |
| Breast cancer | -1.300 | 4.0e-15 |
| colon cancer | -1.700 | 4.4e-02 |
| dermatomyositis | 1.600 | 2.1e-03 |
| gastric cancer | 1.500 | 8.1e-04 |
| glioblastoma | -1.400 | 3.1e-05 |
| group 4 medulloblastoma | 1.100 | 3.5e-03 |
| hepatocellular carcinoma | 1.800 | 2.0e-06 |
| juvenile dermatomyositis | 1.399 | 8.7e-11 |
| malignant mesothelioma | 1.100 | 1.1e-05 |
| medulloblastoma, large-cell | -1.300 | 1.3e-03 |
| Multiple myeloma | 1.234 | 1.7e-02 |
| ovarian cancer | 1.200 | 3.5e-04 |
| pancreatic cancer | 1.300 | 7.1e-03 |
| pancreatic carcinoma | 1.300 | 7.1e-03 |
| tuberculosis | -1.200 | 1.0e-02 |
MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYR 1 - 70 VQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYL 71 - 140 VENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWR 141 - 210 AAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAM 211 - 280 LERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYR 281 - 350 GAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQ 351 - 420 SMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHL 421 - 490 AVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLV 491 - 560 EAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 561 - 627 //
