| Tbio | Protein fem-1 homolog B |
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Comments
| Disease | log2 FC | p |
|---|---|---|
| gastric cancer | 1.500 | 0.001 |
| hepatocellular carcinoma | 1.800 | 0.000 |
| pancreatic cancer | 1.300 | 0.007 |
| Multiple myeloma | 1.234 | 0.017 |
| malignant mesothelioma | 1.100 | 0.000 |
| astrocytic glioma | -1.100 | 0.050 |
| atypical teratoid / rhabdoid tumor | -1.600 | 0.000 |
| glioblastoma | -1.400 | 0.000 |
| medulloblastoma, large-cell | -1.300 | 0.001 |
| juvenile dermatomyositis | 1.399 | 0.000 |
| acute quadriplegic myopathy | 2.097 | 0.000 |
| tuberculosis and treatment for 6 months | 1.900 | 0.000 |
| colon cancer | -1.700 | 0.044 |
| adult high grade glioma | -1.100 | 0.003 |
| group 4 medulloblastoma | 1.100 | 0.004 |
| pancreatic carcinoma | 1.300 | 0.007 |
| Breast cancer | -1.300 | 0.000 |
| ovarian cancer | 1.200 | 0.000 |
| dermatomyositis | 1.600 | 0.002 |
| PMID | Text |
|---|---|
| 24076122 | These findings have implications for understanding the cellular functions of Fem1b, and the regulation of Gli1 oncoprotein activity. |
| 20200332 | Observational study of gene-disease association. (HuGE Navigator) |
| 19948975 | Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) |
| 19908242 | the proapoptotic protein Fem1b is downregulated by the proteasome in malignant colon cancer cells and mediates proteasome inhibitor-induced apoptosis of these cells |
| 19330022 | FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. |
| 18757445 | This study presents evidence suggesting a role for FEM1A and FEM1B in the pathogenesis of polycystic ovary syndrome. Only FEM1B variants were associated with insulin-related traits in PCOS women. |
| 18757445 | Observational study of gene-disease association. (HuGE Navigator) |
MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYR 1 - 70 VQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYL 71 - 140 VENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWR 141 - 210 AAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAM 211 - 280 LERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYR 281 - 350 GAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQ 351 - 420 SMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHL 421 - 490 AVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLV 491 - 560 EAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 561 - 627 //
| PMID | Year | Title |
|---|---|---|
| 24076122 | 2013 | Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1. |
| 23377640 | 2013 | Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. |
| 20200332 | 2010 | Family-based analysis of candidate genes for polycystic ovary syndrome. |
| 19948975 | 2009 | Integrative predictive model of coronary artery calcification in atherosclerosis. |
| 19908242 | 2010 | Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells. |
| 19330022 | 2009 | Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. |
| 18757445 | 2008 | FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 17003112 | 2006 | Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). |
| 16572171 | 2006 | Analysis of the DNA sequence and duplication history of human chromosome 15. |
| More... |
