Tclin KCND3 Potassium voltage-gated channel subfamily D member 3

Protein Summary

Description

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UK17
• O60576
• O60577
• Q14D71
• Q5T0M0
• Q9UH85
• Q9UH86
• Q9UK16

Gene Name

• KCND3

Ensembl ID

• ENST00000302127
• ENSP00000306923
• ENSG00000171385
• ENST00000315987
• ENSP00000319591
• ENST00000369697
• ENSP00000358711

Symbol

• KV4.3
• SCA19
• SCA22
• BRGDA9
• KCND3L
• KCND3S
• KSHIVB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.94
disease perturbation	0.68
PubMedID	0.64
transcription factor	0.61

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / D (Shal) Subfamily / Kv4.3/kcnd3 Sub-subfamily / Potassium Voltage-gated Channel Subfamily D Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.4   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 335.4   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8