Property Summary

NCBI Gene PubMed Count 40
PubMed Score 8.30
PubTator Score 50.78

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Contact Dermatitis 80
Disease Target Count P-value
lung cancer 4473 2.53636353377267E-4
diabetes mellitus 1663 0.0010760694191883
Multiple myeloma 1328 0.00210342937830167
ovarian cancer 8492 0.00501203137253861
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00879162734815784
non primary Sjogren syndrome sicca 840 0.0225938096961109
Disease Target Count Z-score Confidence
Acromesomelic dysplasia 10 4.155 2.1


  Differential Expression (6)

Disease log2 FC p
Multiple myeloma 1.316 0.002
pancreatic ductal adenocarcinoma liver m... -1.697 0.009
lung cancer 1.900 0.000
diabetes mellitus -1.100 0.001
non primary Sjogren syndrome sicca 1.500 0.023
ovarian cancer 1.200 0.005


Accession Q9UJZ1 B4E1K7 D3DRN3 O60376 Q53G29 Q96FY2 Q9P042 SLP-2
Symbols SLP-2


PANTHER Protein Class (1)

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG
Anole lizard OMA EggNOG
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid

Gene RIF (30)

26750533 The significant association of SLP-2 overexpression with unfavorable clinicopathological characteristics and BRAFV600E mutation indicates that SLP-2 may have a role in aggressiveness of BRAF-mutated papillary thyroid carcinoma.
26487491 Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival
25973071 STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer.
25695396 Our study showed that STOML-2 was negatively regulated by miR1207-5p in esophageal carcinoma
24258357 STOML2 may have a role in progression of gastric adenocarcinoma
24190591 SLP-2 was upregulated by TGF-beta1, indicating a possible role of SLP-2 in Papillary thyroid cancer tumorigenesis.
23918306 SLP-2 may play an important role in human GBC tumorigenesis, and SLP-2 might serve as a novel prognostic marker in human GBC.
23874603 A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of stomatin (EPB72)-like 2 (STOML2) expression by HIV-1 Vpr in Vpr transduced macrophages
23667687 Expression of SLP-2 is associated with invasion of esophageal squamous cell carcinoma.
23371255 Increased levels of SLP-2 correlate with lymph node metastasis in gastric cancer.

AA Sequence

DRVKMS                                                                    351 - 356

Text Mined References (49)

PMID Year Title
26750533 2016 Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation.
26487491 2015 Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival.
25973071 2015 Stomatin-like protein 2 expression is associated with clinical survival in patients with cervical cancer.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25695396 2015 miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma.
24337748 2014 Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24258357 2014 Increased expression of stomatin-like protein 2 (STOML2) predicts decreased survival in gastric adenocarcinoma: a retrospective study.
24190591 2014 Stomatin-like protein 2 is associated with the clinicopathological features of human papillary thyroid cancer and is regulated by TGF-? in thyroid cancer cells.
23918306 2014 Clinicopathological significance of SLP-2 overexpression in human gallbladder cancer.